phyloscan identification of transcription factor binding sites using cross-species evidencephyloscan转录因子结合位点的识别使用跨物种的证据.pdf

Algorithms for Molecular Biology BioMed Central Research Open Access PhyloScan: identification of transcription factor binding sites using cross-species evidence 1 1,2 1,3 C Steven Carmack , Lee Ann McCue , Lee A Newberg* and Charles E Lawrence1,4 1 2 Address: The Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA, Pacific Northwest National Laboratory, Richland, WA 99352, USA, 3Departrnent of Computer Science, Rensselaer Polytechnic Institute, Troy, NY 12180, USA and 4Division of Applied Mathematics, Brown University, Providence, RI 02912, USA Email: C Steven Carmack - steve.carmack@; Lee Ann McCue - leeann.mccue@; Lee A Newberg* - lee.newberg@; Charles E Lawrence - charles.lawrence@ * Corresponding author Published: 23 January 2007 Received: 10 July 2006 Accepted: 23 January 2007 Algorithms for Molecular Biology 2007, 2:1 doi:10.1186/1748-7188-2-1 This article is available from: /content/2/1/1 © 2007 Carmack et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: When transcription factor binding sites are known for a particular transcription factor, it is possible to construct a motif model that can be