pkquest capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokineticspkquest局限性毛细血管通透性和血浆蛋白结合,应用人类菊粉,双氯青霉素和头孢曲松钠药物动力学.pdfVIP

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pkquest capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokineticspkquest局限性毛细血管通透性和血浆蛋白结合,应用人类菊粉,双氯青霉素和头孢曲松钠药物动力学.pdf

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pkquest capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokineticspkquest局限性毛细血管通透性和血浆蛋白结合,应用人类菊粉,双氯青霉素和头孢曲松钠药物动力学

BMC Clinical Pharmacology BioMed Central BMC Clinical Pharmacology x 2002, Open Access 2 Research article PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics David G Levitt Address: Department of Physiology, University of Minnesota, 6-125 Jackson Hall, 321 Church St. S. E., Minneapolis, MN 55455, USA E-mail: levitt@ Published: 26 September 2002 Received: 4 April 2002 Accepted: 26 September 2002 BMC Clinical Pharmacology 2002, 2:7 This article is available from: /1472-6904/2/7 © 2002 Levitt; licensee BioMed Central Ltd. This article is published in Open Access: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount of plasma protein binding because the effective capillary permeability depends on the product of the intrinsic capillary permeability (PS) and the fraction of solute that is free in the blood (fwB). PKQuest, a new generic physiologically based pharmacokinetic software routine (PBPK), provides a novel approach to modeling capillary permeability in which the only adj