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pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration a pilot study期间danaparoid venovenous血液滤过的药代学和药效学试验研究.pdf

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pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration a pilot study期间danaparoid venovenous血液滤过的药代学和药效学试验研究

Available online /content/11/5/R102 Vol 11 No 5 Open Access Research Pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study 1 1,2 3 4 Anne-Cornélie JM de Pont , Jorrit-Jan H Hofstra , Derk R Pik , Joost CM Meijers and Marcus J Schultz1,2 1Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 2Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 3Faculty of Science, University of Leiden, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands 4Laboratory of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Corresponding author: Anne-Cornélie JM de Pont, a.c.depont@amc.uva.nl Received: 22 Jun 2007 Revisions requested: 25 Jul 2007 Revisions received: 27 Aug 2007 Accepted: 13 Sep 2007 Published: 13 Sep 2007 Critical Care 2007, 11:R102 (doi:10.1186/cc6119) This article is online at: /content/11/5/R102 © 2007 de Pont et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background In patients with suspected heparin-induced was administered as a continuous infusion of 100 anti-Xa-U/