pharmacokinetics and lung delivery of pdds-aerosolized amikacin (nktr-061) in intubated and mechanically ventilated patients with nosocomial pneumonia药物动力学和肺部的交付pdds-aerosolized阿米卡星(nktr - 061)在气管插管和机械通气患者院内肺炎.pdfVIP
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pharmacokinetics and lung delivery of pdds-aerosolized amikacin (nktr-061) in intubated and mechanically ventilated patients with nosocomial pneumonia药物动力学和肺部的交付pdds-aerosolized阿米卡星(nktr - 061)在气管插管和机械通气患者院内肺炎
Available online /content/13/6/R200
Vol 13 No 6 Open Access
Research
Pharmacokinetics and lung delivery of PDDS-aerosolized
amikacin (NKTR-061) in intubated and mechanically ventilated
patients with nosocomial pneumonia
1 2 3 4 5
Charles-Edouard Luyt , Marc Clavel , Kalpalatha Guntupalli , Jay Johannigman , John I Kennedy ,
6 7 8 1
Christopher Wood , Kevin Corkery , Dennis Gribben and Jean Chastre
1Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Paris-Pierre-et-Marie-
Curie, 47 boulevard de lHôpital, 75651 Paris Cedex 13, France
2Service de Réanimation Médicale, Centre Hospitalier Dupuytren, 2 avenue Martin Luther King, 87000 Limoges, France
3Critical Care, Baylor College of Medicine, One Baylor Plazza, Houston, TX 77030, USA
4Department of Surgery, Division of Trauma/Critical Care, University of Cincinnati, 2600 Clifton Avenue, Cincinnati, OH 45221, USA
5Division of Pulmonary and Critical Care Medicine, University of Alabama, 1802 6th Avenue South, Birmingham, AL 35249, USA
6Critical Care Department, University of Tennessee Health Science Center, 920 Madison Avenue, Memphis, TN 38163, USA
7Novartis Pharmaceutical Corp, 150 Industrial Road, San Carlos, CA 94070, USA
8Talima Therapeutics, 75 Shoreway Road, San Carlos, CA 94070, USA
Corresponding author: Charles-Edouard Luyt, charles-edouard.luyt@psl.aphp.fr
Received: 30 Nov 2008 Revisions requested: 19 Feb 2009 Revisions received: 19 Mar 2009 Accepted:
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