原创力文档pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status脓毒性休克患者的药物动力学的肾上腺素modelization和互动与内源性神经激素的状态.pdfVIP
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pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status脓毒性休克患者的药物动力学的肾上腺素modelization和互动与内源性神经激素的状态
Available online /content/13/4/R120
Vol 13 No 4 Open Access
Research
Pharmacokinetics of epinephrine in patients with septic shock:
modelization and interaction with endogenous neurohormonal
status
1 1 2 1 3
Imad Abboud , Nicolas Lerolle , Saik Urien , Jean-Marc Tadié , Françoise Leviel , Jean-
Yves Fagon1 and Christophe Faisy1
1Medical Intensive Care Unit, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris – Descartes, Paris,
France
2E.A. 3620, CIC-0109 Cochin-Necker Paris Descartes, Unité de Recherche Clinique, Tarnier Hospital, Assistance Publique-Hôpitaux de Paris,
Université Paris – Descartes, Paris, France
3Department of Physiology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris – Descartes, Paris, France
Corresponding author: Nicolas Lerolle, nilerolle@chu-angers.fr
Received: 20 Mar 2009 Revisions requested: 24 Apr 2009 Revisions received: 26 Jun 2009 Accepted: 21 Jul 2009 Published: 21 Jul 2009
Critical Care 2009, 13:R120 (doi:10.1186/cc7972)
This article is online at: /content/13/4/R120
© 2009 Abboud et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction In septic patients, an unpredictable response to Results Plasma epinephrine concentrations ranged from 4.4 to
epinephrine may be due to pharmacodynamic factors or to non-
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