plasmacytoid dendritic cells and the control of herpesvirus infections血浆树突细胞和疱疹病毒感染的控制.pdfVIP
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plasmacytoid dendritic cells and the control of herpesvirus infections血浆树突细胞和疱疹病毒感染的控制
Viruses 2009, 1, 383-419; doi:10.3390/v1030383
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
Plasmacytoid Dendritic Cells and the Control of Herpesvirus
Infections
Thomas Baranek 1,2,3,#, Nicolas Zucchini 1,2,3,# and Marc Dalod 1,2,3,*
1 Université de la Méditerranée, Centre d’Immunologie de Marseille-Luminy, Parc Scientifique
Technologique de Luminy, Case 906, F13288 Marseille, Cedex 09, France;
E-Mails: baranek@ciml.univ-mrs.fr (T.B.); zucchini@ciml.univ-mrs.fr (N.Z.)
2 Institut National de la Santé et de la Recherche Médicale (INSERM), U631, Centre d’Immunologie
de Marseille-Luminy, Parc Scientifique Technologique de Luminy, Case 906, F13288 Marseille,
Cedex 09, France
3 Centre National de la Recherche Scientifique (CNRS), UMR6102, Centre d’Immunologie de
Marseille-Luminy, Parc Scientifique Technologique de Luminy, Case 906, F13288 Marseille,
Cedex 09, France
* Author to whom correspondence should be addressed; E-Mail: dalod@ciml.univ-mrs.fr;
Tel.: +33 4 91 26 94 51; Fax: +33 4 91 26 94 30.
# These authors contributed equally to this work.
Received: 10 August 2009; in revised form: 1 October 2009 / Accepted: 8 October 2009 /
Published: 14 October 2009
Abstract: Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral
defense, including against herpesviruses. IFN-I have potent direct antiviral activities and
also mediate a multiplicity of immunoregulatory functions, which can either promote or
dampen antiviral adaptive immune responses. Plasmacytoid
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