phenoxypropylamines synthesis and antiulcer evaluationphenoxypropylamines合成和抗溃疡的评估.pdfVIP

Molecules 2009, 14, 1818-1824; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Phenoxypropylamines: Synthesis and Antiulcer Evaluation Hui Zhang 1,2,*, Bao-Yan Zhang 1, Qian-Yun Zhang 3, Dong-Mei Zhao 4 and Jia-Mei Wang 5 1 College of Sciences, Northeastern University, Shenyang 110004, China; E-mail: baoyanzhang2005@126.com (B-Y.Z.) 2 Department of Chemistry, Shenyang Medical College, Shenyang 110034, China; 3 School of Public Health, China Medical University, Shenyang 110001, China; E-mail: iamxiaoqian@126.com (Q-Y.Z.) 4 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; E-mail: dongmeiz-67@163.com (D-M.Z.) 5 School of Medicinal Application Technology, Shenyang Medical College, Shenyang 110034, China; E-mail: jinxin126.com (J-M.W.) * Author to whom correspondence should be addressed; E-mail: 163.com; Tel.: +86- 24 Fax: +86-24 Received: 9 April 2009 in revised form: 4 May 2009 / Accepted: 08 May 2009 / Published: 13 May 2009 Abstract: We have synthesized a number of phenoxypropylamines from N-{3-[3-(1- piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, 1H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of them showed significant gastric acid antisecretory activity. Keywords: roxatidine; synthesis;