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pdgfvegf signaling controls cell size in drosophilapdgfvegf信号控制细胞大小在果蝇.pdf

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pdgfvegf signaling controls cell size in drosophilapdgfvegf信号控制细胞大小在果蝇

Volume 10, Issue 2, Article R20et al.Sims2009 Open Access Research PDGF/VEGF signaling controls cell size in Drosophila David Sims*†, Peter Duchek*‡ and Buzz Baum*§ Addresses: *Morphogenesis Group, Ludwig Institute for Cancer Research (UCL Branch), Riding House Street, London, W1W 7BS, UK. †Current address: The Breakthrough Toby Robins Breast Cancer Research Centre at the Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB, UK. ‡Current address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse, 1030 Vienna, Austria. §Current address: MRC Laboratory for Molecular and Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. Correspondence: Buzz Baum. Email: b.baum@ucl.ac.uk Published: 12 February 2009 Received: 21 November 2008 Accepted: 12 February 2009 Genome Biology 2009, 10:R20 (doi:10.1186/gb-2009-10-2-r20) The electronic version of this article is the complete one and can be found online at /2009/10/2/R20 © 2009 Sims et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. cells, as regulators of cell growth./pPvr and cell growthpPvr and its ligands, Pvf 2 and 3, which are upstream of Ras and PI3kinase, are identified from a genome-wide screen in Drosophila Abstract Background: In multicellular animals, cell size is controlled by a limited set of conserved intracellular signaling pathways, which when deregulated contribute to tumorigen