phenylmethimazole blocks dsrna-induced irf3 nuclear translocation and homodimerizationphenylmethimazole块dsrna-induced irf3核易位和homodimerization.pdfVIP

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phenylmethimazole blocks dsrna-induced irf3 nuclear translocation and homodimerizationphenylmethimazole块dsrna-induced irf3核易位和homodimerization.pdf

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phenylmethimazole blocks dsrna-induced irf3 nuclear translocation and homodimerizationphenylmethimazole块dsrna-induced irf3核易位和homodimerization

Molecules 2012, 17, 12365-12377; doi:10.3390/molecules171012365 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization Maria C. Courreges 1, Noriko Kantake 1,2, Douglas J. Goetz 3,4, Frank L. Schwartz 1,3,5 and Kelly D. McCall 1,3,5,6,7,* 1 Department of Specialty Medicine, Ohio University, Athens, OH 45701, USA 2 Interthyr Corporation, Athens, OH 45701, USA 3 Biomedical Engineering Program, Ohio University Russ College of Engineering Technology, Ohio University, Athens, OH 45701, USA 4 Department of Chemical and Biomolecular Engineering, Ohio University Russ College of Engineering Technology, Ohio University, Athens, OH 45701, USA 5 Diabetes Institute, Ohio University College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA 6 Department of Biological Sciences, Ohio University College of Arts Sciences, Ohio University, Athens, OH 45701, USA 7 Molecular Cellular Biology Program, Ohio University College of Arts Sciences, Ohio University, Athens, OH 45701, USA * Author to whom correspondence should be addressed; E-Mail: mccallk@; Tel.: +1-740-593-0926; Fax: +1-740-597-1371. Received: 5 October 2012; in revised form: 16 October 2012 / Accepted: 19 October 2012 / Published: 22 October 2012 Abstract: Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling. In the present study, we investigated the mole