p-cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activationp-cymene能保护小鼠免受lipopolysaccharide-induced急性肺损伤通过抑制炎症细胞的活化.pdfVIP

下载本文档

2
0
约3.84万字
约 15页
2017-09-11 发布于上海
举报
版权申诉

p-cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activationp-cymene能保护小鼠免受lipopolysaccharide-induced急性肺损伤通过抑制炎症细胞的活化.pdf

1、本文档共15页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

p-cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activationp-cymene能保护小鼠免受lipopolysaccharide-induced急性肺损伤通过抑制炎症细胞的活化

Molecules 2012, 17, 8159-8173; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article p -Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation Guanghong Xie †, Na Chen †, Lanan Wassy Soromou, Fang Liu, Ying Xiong, Qianchao Wu, Hongyu Li, Haihua Feng * and Guowen Liu * College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: fhh70@163.com (H.F.); liuguowen2008@163.com (G.L.). Received: 5 May 2012; in revised form: 3 July 2012 / Accepted: 4 July 2012 / Published: 6 July 2012 Abstract: The objective of this study was to test the hypothesis that p -cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p -cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inﬂammatory cell inﬁltration, lung tissue myeloperoxidase activity. In addition, p -cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p -cymene treatment markedly decreased focal thickening,