platelet-activating factor (paf) antagonistic activity of a new biflavonoid from garcinia nervosa var. pubescens kingplatelet-activating因子(paf)参谋长敌对活动的新biflavonoid从藤黄属植物神经衰弱var.下毛竹王.pdfVIP

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platelet-activating factor (paf) antagonistic activity of a new biflavonoid from garcinia nervosa var. pubescens kingplatelet-activating因子(paf)参谋长敌对活动的新biflavonoid从藤黄属植物神经衰弱var.下毛竹王.pdf

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platelet-activating factor (paf) antagonistic activity of a new biflavonoid from garcinia nervosa var. pubescens kingplatelet-activating因子(paf)参谋长敌对活动的新biflavonoid从藤黄属植物神经衰弱var.下毛竹王

Molecules 2012, 17, 10893-10901; doi:10.3390/molecules170910893 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Platelet-Activating Factor (PAF) Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens King Juriyati Jalil 1,*, Ibrahim Jantan 1, Azura Abdul Ghani 1 and Shahnaz Murad 2 1 Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia 2 Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia * Author to whom correspondence should be addressed; E-Mail: juriyati@pharmacy.ukm.my; Tel.: +603-9289-7533; Fax: +603-2698-3271. Received: 30 July 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 10 September 2012 Abstract: The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4,II-4-hexahydroxy-(I-3,II-8)-flavonylflavanonol together with two known flavonoids, 6-methyl-4-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC50 values of 28.0 and 20