platinum-catalyzed hydrative cyclization of 1,6-diynes for the synthesis of 3,5-substituted conjugated cyclohexenonesplatinum-catalyzed hydrative环合,6-diynes 3的合成,5-substituted共轭cyclohexenones.pdfVIP

下载本文档

1
0
约3.32万字
约 8页
2017-09-11 发布于上海
举报
版权申诉

platinum-catalyzed hydrative cyclization of 1,6-diynes for the synthesis of 3,5-substituted conjugated cyclohexenonesplatinum-catalyzed hydrative环合,6-diynes 3的合成,5-substituted共轭cyclohexenones.pdf

1、本文档共8页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

platinum-catalyzed hydrative cyclization of 1,6-diynes for the synthesis of 3,5-substituted conjugated cyclohexenonesplatinum-catalyzed hydrative环合,6-diynes 3的合成,5-substituted共轭cyclohexenones

Molecules 2010, 15, 5045-5052; doi:10.3390/molecules OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones Chen Zhang 1, Jian-Feng Qi 1, Dong-Mei Cui 2,*, Qian Wang 2 and Xiu-Li Wang 3 1 School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 2 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China 3 College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, Guilin, China * Author to whom correspondence should be addressed; E-Mail: cuidongmei@; Tel.: 86-571 Fax: 86-571 Received: 4 June 2010; in revised form: 24 June 2010 / Accepted: 5 July 2010 / Published: 23 July 2010 Abstract: We have developed a Pt(COD)Cl -catalyzed hydrative cyclization of 1,6-diynes 2 leading to the formation of functionalized cyclohexenones in good yields. Keywords: diyne; catalysis; hydrative cyclization; cyclohexenones 1. Introduction Cyclohexenone derivatives are not only key intermediates in organic synthesis, but they also exhibit important pharmacological activities [1-4]. Extensive synthetic efforts for conjugate cyclohexenones have been reported, in which an annulation approach from acyclic precursors constitutes a useful entry [5-13]. Despite this advance, there is still a great need to develop more convenient catalytic systems that can accommodate such