platycoside n a new oleanane-type triterpenoid saponin from the roots of platycodon grandiflorumplatycoside n新oleanane-type桔梗根的三萜皂苷.pdfVIP

Molecules 2010, 15, 8702-8708; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum Wei Li 1,†, Wei Zhang 1,†, Lan Xiang 2, Zi Wang 1, Yi-Nan Zheng 1,*, Ying-Ping Wang 3,*, 1 4 Jing Zhang and Li Chen 1 College of Chinese Material Medicine, Jilin Agricultural University, Changchun 130118, China; E-Mail: liwei7727@126.com (W.L.) 2 School of Pharmacy, Shangdong University, Jinan 250012, China 3 Institute of Special Wild Economic Animals and Plant, CAAS, Jilin 132109, China 4 Norman Bethune College of Medicine, Jilin University, Changchun 130021, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mail: zhenyinan@ (Y.N. Z.); E-Mail: yingpingw@126.com (Y.P.W.) Tel.: +86-432Y.P.W.); Fax: +86-432Y.P.W.). Received: 13 September 2010; in revised form: 22 November 2010 / Accepted: 25 November 2010 / Published: 30 November 2010 Abstract: A new oleanane-type triterpenoid saponin, named platycoside N (1), together with six known saponins, was isolated from the roots of Platycodon grandiflorum . On the basis of acid hydrolysis, comprehensive spectroscopic data analyses and comparison with the spectral data of the known compounds, its structure was elucidated as 3-O-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl-2β,3β,16α,23-tetrahydroxyolean-12-en-28-oic acid 28-O-β-L