platelet-derived growth factor (pdgf)pdgf receptors (pdgfr) axis as target for antitumor and antiangiogenic therapy血小板源生长因子(pdgf)pdgf受体(pdgfr)轴作为抗肿瘤和抗血管新生治疗的目标.pdfVIP

下载本文档

0
0
约10.66万字
约 28页
2017-09-11 发布于上海
举报
版权申诉

platelet-derived growth factor (pdgf)pdgf receptors (pdgfr) axis as target for antitumor and antiangiogenic therapy血小板源生长因子(pdgf)pdgf受体(pdgfr)轴作为抗肿瘤和抗血管新生治疗的目标.pdf

1、本文档共28页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

platelet-derived growth factor (pdgf)pdgf receptors (pdgfr) axis as target for antitumor and antiangiogenic therapy血小板源生长因子(pdgf)pdgf受体(pdgfr)轴作为抗肿瘤和抗血管新生治疗的目标

Pharmaceuticals 2010, 3, 572-599; doi:10.3390/ph3030572 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy Marius Raica * and Anca Maria Cimpean Department of Histology and Molecular Pathology, “Victor Babes” University of Medicine and Pharmacy, Pta Eftimie Murgu 2, 300041 Timisoara, Romania; E-Mail: acimpeanu@umft.ro (A.M.C.) * Author to whom correspondence should be addressed; E-Mail: raica@umft.ro; Tel: +40-256-204-476; Fax: +40-256-490-626. Received: 28 January 2010; in revised form: 16 February 2010 / Accepted: 9 March 2010 / Published: 11 March 2010 Abstract: Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF), fibroblast growth factor (FGF)-2 or platelet-derived growth factors (PDGF). From these, VEGF and FGF-2 were extensively investigated and it was shown that they significantly contribute to the induction and progression of angiogenesis. A lot of evidence has been accumulated in last 10 years that supports the contribution of PDGF/PDGFR axis in developing angiogenesis in both normal and tumoral conditions. The crucial role of PDGF-B and PDGFR-β in angiogenesis has been demonstr