platycoside o, a new triterpenoid saponin from the roots of platycodon grandiflorumplatycoside o,桔梗根的新三萜皂苷.pdfVIP

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platycoside o, a new triterpenoid saponin from the roots of platycodon grandiflorumplatycoside o,桔梗根的新三萜皂苷.pdf

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platycoside o, a new triterpenoid saponin from the roots of platycodon grandiflorumplatycoside o,桔梗根的新三萜皂苷

Molecules 2011, 16, 4371-4378; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Platycoside O, a New Triterpenoid Saponin from the Roots of Platycodon grandiflorum Wen-Wei Fu 1,2,3,4,*, Jin-Nan Fu 5, Wen-Meng Zhang 6, Li-Xin Sun 6, Yue-Hu Pei 6 and Ping Liu 3.4,* 1 Institute of Liver Diseases, Shanghai Shuguang Hospital, Shanghai 201203, China 2 Shanghai Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai Shuguang Hospital, Shanghai 201203, China 3 Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 4 E-Institute of Traditional Chinese Medicine Internal Medicine in Shanghai University, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 5 Institute of Microbiology, Jiangxi Academy of Sciences, Nanchang 330029, China 6 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China * Authors to whom correspondence should be addressed; E-Mails: fuwenwei@ (W.-W.F.); liuliver@ (P.L.); Tel.: +86-21 Fax: +86-21 Received: 25 March 2011; in revised form: 13 May 2011 / Accepted: 18 May 2011 / Published: 26 May 2011 Abstract: A new unusual minor triterpenoid saponin, platycoside O (1), was isolated from the 75% EtOH extract obtained from the roots of Platycodon grandiflorum, together with four known saponins: platycoside M-3 (2), platycoside J (3), platycoside F (4) and platycoside B (5). The structure of 1 was determined as 3-O-β-D-glucopyranosyl-(1→6)-β- D-