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polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for dna, shrna and sirnapolyamidoamine树形分子与环糊精轭合物的新载体dna,成分和核.pdf

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polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for dna, shrna and sirnapolyamidoamine树形分子与环糊精轭合物的新载体dna,成分和核

Pharmaceutics 2012, 4, 130-148; doi:10.3390/pharmaceutics4010130 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA Hidetoshi Arima *, Keiichi Motoyama and Taishi Higashi Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; E-Mails: motoyama@kumamoto-u.ac.jp (K.M.); higashit@kumamoto-u.ac.jp (T.H.) * Author to whom correspondence should be addressed; E-Mail: arimah@gpo.kumamoto-u.ac.jp; Tel.: +81-96-371-4160; Fax: +81-96-371-4420. Received: 4 January 2012; in revised form: 20 January 2012 / Accepted: 20 January 2012 / Published: 1 February 2012 Abstract: Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) StarburstTM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery. Keywords: cyclodextrin; polyamidoamine