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potent anti-platelet constituents from centaurea iberica有效的抗血小板成分的矢车菊属iberica
Molecules 2011, 16, 2053-2064; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Potent Anti-Platelet Constituents from Centaurea iberica
Amna Nisar Khan 1, Itrat Fatima 1, Urooj Abdul Khaliq 1, Abdul Malik 1,*, Ghulam Abbas
2 3 3
Miana , Zia-ur-Rehman Qureshi and Huma Rasheed
1 International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry,
University of Karachi, Karachi 75270, Pakistan
2 th
Riphah Institute of Pharmaceutical Sciences, Riphah International University, 7 Avenue,
G-7/4 Islamabad, Pakistan
3 International Centre for Chemical and Biological Sciences, Dr. Panjwani Centre for Molecular
Medicine and Drug Research, University of Karachi, Karachi 75270, Pakistan
* Author to whom correspondence should be addressed; E-Mail: abdul.malik@;
Tel.: +92 21-2824926; Fax: +92 21-4819018.
Received: 3 January 2011; in revised form: 24 February 2011 / Accepted: 26 February 2011 /
Published: 28 February 2011
Abstract: New naturally occurring nitrogenous compounds 1 and 2, along with a new
dimeric lignan glucoside 3, have been isolated from the ethyl acetate soluble fraction of
Centaurea iberica. Their structures have been elucidated through spectroscopic techniques.
All the isolated compounds showed significant platelet aggregation inhibition.
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