potential role of ifnα in adult lupusifnα在成人红斑狼疮的潜在作用.pdfVIP

Rönnblom Arthritis Research Therapy 2010, 12(Suppl 1):S3 /content/12/S1/S3 R E V I E W Potential role of IFNα in adult lupus Lars Rönnblom* reason for this is that a large number of diff erent auto- Abstract antibodies are produced in lupus patients and that most, Patients with lupus have a continuous production if not all, cells in the immune system seem to be involved of IFNα and display an increased expression of IFNα- in the disease process. regulated genes. The reason for the ongoing IFNα h e most prominent feature in lupus is an immune synthesis in these patients seems to be an activation response to nucleic acid and associated proteins, which of plasmacytoid dendritic cells (pDCs) by immune results in autoantibody production, immune complex complexes (ICs), consisting of autoantibodies in (IC) formation and organ infl ammation. In addition, combination with DNA-containing or RNA-containing most lupus patients display several signs of an increased autoantigens. The mechanisms behind the activation IFNα production, which during the past years has of pDCs by such ICs have to some extent been attracted much interest regarding the possible role of this elucidated during the last years. Thus, interferogenic cytokine in the disease process. h is interest has been ICs are internalized via the FcγRIIa expressed on pDCs, further inspired by the observation that IFNα adminis- reach the