prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight archived samples from the child health and development studies pregnancy cohort产前多氯联苯暴露与出生体重降低妊娠期长度但不存档样本怀孕队列研究儿童健康和发展.pdfVIP

Kezios et al. Environmental Health 2012, 11:49 /content/11/1/49 RESEARCH Open Access Prenatal polychlorinated biphenyl exposure is associated with decreased gestational length but not birth weight: archived samples from the Child Health and Development Studies pregnancy cohort 1 2 3 4 5 5 5 Katrina L Kezios , Xinhua Liu , Piera M Cirillio , Olga I Kalantzi , Yunzhu Wang , Myrto X Petreas , June-Soo Park , Gary Bradwin6, Barbara A Cohn3 and Pam Factor-Litvak1* Abstract Background: Polychlorinated biphenyls (PCBs), known endocrine disruptors, were banned in 1979 but persist in the environment. Previous studies are inconsistent regarding prenatal exposure to PCBs and pregnancy outcomes. We investigated associations between prenatal exposure to PCBs and gestational length and birth weight. Methods: In a sample of 600 infants (born between 1960 and 1963) randomly selected from Child Health and Development Studies participants followed through adolescence we measured 11 PCB congeners in maternal post partum sera (within three days of delivery). Length of gestation was computed from the reported first day of the last menstrual period (LMP) and delivery date. Linear regression was used to estimate associations between PCB exposure and gestational age and birth weight, adjusting for potential confounders. PCBs were grouped according to hypothesized biological action (1b (sum of weak phenobarbital inducers), 2b (sum of limited dioxin activity), and 3 (sum of CYP1A and CYP2b inducers)) or degree of ortho- substitution (mono, di, tri). Secondary analyses examined associations between total PCB exposure and exposure to individual congeners. Results: Each unit increase in mono-ortho substituted PCBs was