proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis在羊半月板切除术模型差别蛋白多糖4对这些早期骨关节炎.pdfVIP

Available online /content/8/2/R41 Vol 8 No 2 Open Access Research article Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis 1 2 1 1 3 Allan A Young , Susan McLennan , Margaret M Smith , Susan M Smith , Martin A Cake , 3 1 1 4 Richard A Read , James Melrose , David H Sonnabend , Carl R Flannery and Christopher B Little1 1Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Pacific Highway, St Leonards, NSW 2065, Australia 2Department of Endocrinology, Royal Prince Alfred Hospital and Department of Medicine, University of Sydney, Missenden Road, Camperdown, NSW 2050, Australia 3School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia 4Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA Corresponding author: Allan A Young, al_young@ Received: 23 Nov 2005 Revisions requested: 20 Dec 2005 Revisions received: 10 Jan 2006 Accepted: 12 Jan 2006 Published: 31 Jan 2006 Arthritis Research Therapy 2006, 8:R41 (doi:10.1186/ar1898) This article is online at: /content/8/2/R41 © 2006 Young et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Osteoarthritis is a disease of