原创力文档probe-level estimation improves the detection of differential splicing in affymetrix exon array studiesprobe-level估计改进的微分拼接检测affymetrix外显子阵列的研究.pdfVIP
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probe-level estimation improves the detection of differential splicing in affymetrix exon array studiesprobe-level估计改进的微分拼接检测affymetrix外显子阵列的研究
Volume 10, Issue 7, Article R77et al.Laajala2009 Open Access
Method
Probe-level estimation improves the detection of differential
splicing in Affymetrix exon array studies
* *† * *†
Essi Laajala , Tero Aittokallio , Riitta Lahesmaa and Laura L Elo
Addresses: *Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, FI-20521, Finland. †Department of
Mathematics, University of Turku, Turku, FI-20014, Finland.
Correspondence: Laura L Elo. Email: laliel@utu.fi
Published: 16 July 2009 Received: 16 March 2009
Revised: 5 June 2009
Genome Biology 2009, 10:R77 (doi:10.1186/gb-2009-10-7-r77)
Accepted: 16 July 2009
The electronic version of this article is the complete one and can be
found online at /2009/10/7/R77
© 2009 Laajala et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
pDetecting differential splicingpA novel statistical procedure is presented that uses probe-level information on Affymetrix exon arrays to detect differential splicing./
Abstract
The recent advent of exon microarrays has made it possible to reveal differences in alternative
splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage
of the probe-lev
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