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probiotics and atopic dermatitis in children儿童益生菌和过敏性皮炎.pdf

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probiotics and atopic dermatitis in children儿童益生菌和过敏性皮炎

Pharmaceuticals 2012, 5, 727-744; doi:10.3390/ph5070727 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Probiotics and Atopic Dermatitis in Children Fabio Meneghin *, Valentina Fabiano, Chiara Mameli and Gian Vincenzo Zuccotti Department of Pediatrics, Luigi Sacco Hospital, Università degli Studi di Milano, Via GB Grassi 74, 20157 Milan, Italy; E-Mails: fabiano.valentina@hsacco.it (V.F.); mameli.chiara@hsacco.it (C.M.); gianvincenzo.zuccotti@unimi.it (G.V.Z.) * Author to whom correspondence should be addressed; E-Mail: meneghin.fabio@hsacco.it; Tel: +39-02-3904-2253, Fax: +39-02-3904-2254. Received: 12 April 2012; in revised form: 26 June 2012 / Accepted: 29 June 2012 / Published: 6 July 2012 Abstract: There is increasing interest in the potential beneficial role of probiotic supplementation in the prevention and treatment of atopic diseases in children. Probiotics are defined as ingested live microorganisms that, when administered in an adequate amount, confer a health benefit to the host. They are mainly represented by Lactobacilli and Bifidobacteria. Several epidemiological data demonstrate that intestinal microflora of atopic children is different from the one of healthy children. Many literature data show that probiotics may modulate the intestinal microflora composition and may have immunomodulatory effect. Based on this hypothesis, probiotics are supposed to confer benefits to allergic diseases.