preparation and physical properties of chitosan benzoic acid derivatives using a phosphoryl mixed anhydride system壳聚糖的制备和物理性质使用磷酰基苯甲酸衍生物混合酸酐体系.pdfVIP

Molecules 2012, 17, 2231-2239; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Preparation and Physical Properties of Chitosan Benzoic Acid Derivatives Using a Phosphoryl Mixed Anhydride System 1 2 1 1 1 Duckhee Lee , Zhe Shan Quan , Chichong Lu , Jin Ah Jeong , Changhyun Song , Mi-Sun Song 1 and Kyu Yun Chai 1,* 1 The Division of Bio-Nanochemistry, The College of Natural Sciences, The Wonkwang University, Iksan City, Chonbuk, 570-749, Korea; E-Mails: dl202@wonkwang.ac.kr (D.L.); chichonglu@ (C.L.); mi_in_black@ (J.A.J.); schh1004@ (C.S.); misun4y@ (M.-S.S.) 2 College of Pharmacy, Yanbian University, Yanji 133000, China; E-Mail: quanzheshan@ * Author to whom correspondence should be addressed; E-Mail: geuyoon@wonkwang.ac.kr; Tel.: +82-63-850-6230; Fax: +82-63-841-4893. Received: 1 January 2012; in revised form: 15 February 2012 / Accepted: 16 February 2012 / Published: 22 February 2012 Abstract: Direct benzoylation of the two hydroxyl groups on chitosan was achieved using a phosphoryl mixed anhydride system, derived from trifluoroacetic anhydride (TFAA), benzoic acids (BAs), and phosphoric acid (PA). The reaction is operated as a one pot process under mild conditions that does not require neither an inert atmosphere nor dry solvents. The structures of the synthesized compounds were confirmed