原创力文档potential link between caffeine consumption and pediatric depression a case-control study咖啡因摄入量之间的潜在联系,儿童抑郁症病例对照研究.pdfVIP
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potential link between caffeine consumption and pediatric depression a case-control study咖啡因摄入量之间的潜在联系,儿童抑郁症病例对照研究
Benko et al. BMC Pediatrics 2011, 11:73
/1471-2431/11/73
RESEARCH ARTICLE Open Access
Potential link between caffeine consumption and
pediatric depression: A case-control study
1,2,3 1,2,4 1,2 5 5
Cássia R Benko , Antonio C Farias , Lucilene G Farias , Erico F Pereira , Fernando M Louzada and
Mara L Cordeiro1,2,6*
Abstract
Background: Early-onset depressive disorders can have severe consequences both from developmental and
functional aspects. The etiology of depressive disorders is complex and multi-factorial, with an intricate interaction
among environmental factors and genetic predisposition. While data from studies on adults suggest that caffeine is
fairly safe, effects of caffeine in children, who are in period of rapid brain development, are currently unknown.
Furthermore, systematic research addressing the relationship between depressive symptoms in children and
caffeine consumption is lacking.
The present study examined the effects of caffeine consumption on depressed mood in children with depression
and non-depressed participants.
Methods: Children and adolescents (n = 51) already enrolled in an ongoing longitudinal study, aged 9-12 years,
were assessed for depressive symptoms with the Children Depressive Inventory (CDI). Psychopathological
symptoms were assessed with the Child Behavioral Checklist (CBCL) and eating habits were assessed with the
Nutrition-Behavior Inventory (NBI) [1]. The children were compared to control children without psychopathology
attending public schools in a Southern Brazilian city.
Results: Participants with CDI scores ≥ 15 (mean = 19; S.D. = 4) also had high NBI scores (mean = 52; S.D. = 19, p
0.001) suggestive of a relationship between depr
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