原创力文档probability-based model of protein-protein interactions on biological timescales蛋白质相互作用的生物时间尺度概率模型.pdfVIP
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probability-based model of protein-protein interactions on biological timescales蛋白质相互作用的生物时间尺度概率模型
Algorithms for Molecular Biology BioMed Central
Research Open Access
Probability-based model of protein-protein interactions on
biological timescales
Alexander L Tournier*, Paul W Fitzjohn and Paul A Bates*
Address: Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3PX, UK
Email: Alexander L Tournier* - Alexander.tournier@.uk; Paul W Fitzjohn - paul.fitzjohn@.uk;
Paul A Bates* - paul.bates@.uk
* Corresponding authors
Published: 11 December 2006 Received: 25 September 2006
Accepted: 11 December 2006
Algorithms for Molecular Biology 2006, 1:25 doi:10.1186/1748-7188-1-25
This article is available from: /content/1/1/25
© 2006 Tournier et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Simulation methods can assist in describing and understanding complex networks
of interacting proteins, providing fresh insights into the function and regulation of biological
systems. Recent studies have investigated such processes by explicitly modelling the diffusion and
interactions of individual molecules. In these approaches, two entities are considered to have
interacted if they come within a set cutoff distance of each other.
Results: In this study, a new model of bimolecular interactions is presented that uses a simple,
pro
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