pro-apoptotic bid is required for the resolution of the effector phase of inflammatory arthritispro-apoptotic投标需要解决的效应阶段炎症性关节炎.pdfVIP
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pro-apoptotic bid is required for the resolution of the effector phase of inflammatory arthritispro-apoptotic投标需要解决的效应阶段炎症性关节炎
Available online /content/9/3/R49
Vol 9 No 3 Open Access
Research article
Pro-apoptotic Bid is required for the resolution of the effector
phase of inflammatory arthritis
1 1 1 2 1,2
John C Scatizzi , Jack Hutcheson , Emily Bickel , G Kenneth Haines III and Harris Perlman
1Saint Louis University, School of Medicine, Department of Molecular Microbiology and Immunology, Saint Louis, MO 63104, USA
2Yale University, School of Medicine, Department of Pathology, New Haven CT 06510, USA
Corresponding author: Harris Perlman, perlmanh@
Received: 12 Feb 2007 Revisions requested: 16 Mar 2007 Revisions received: 10 Apr 2007 Accepted: 17 May 2007 Published: 17 May 2007
Arthritis Research Therapy 2007, 9:R49 (doi:10.1186/ar2204)
This article is online at: /content/9/3/R49
© 2007 Scatizzi et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Rheumatoid arthritis is an autoimmune disease characterized by delay in the resolution of K/BxN serum transfer-induced arthritis.
hyperplasia of the synovial lining and destruction of cartilage and Bid-/- mice display increased inflammation, bone destruction,
bone. Recent studies have suggested that a lack of apoptosis and pannus formation compared to wild-type mice. Furthermore,
contributes to the hyperplasia of the synovial lining and to the Bi
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