psychotropic drugs and the risk of fractures in old age a prospective population-based study精神药品和老年骨折的风险潜在人群为基础的研究.pdfVIP

Nurminen et al. BMC Public Health 2010, 10:396 /1471-2458/10/396 R E S E A R C H A R T I C L E Open Access Research article Psychotropic drugs and the risk of fractures in old age: a prospective population-based study 1,2 1,3 1 4 1,5 Janne Nurminen* , Juha Puustinen , Maarit Piirtola , Tero Vahlberg and Sirkka-Liisa Kivelä Abstract Background: There is evidence that the use of any psychotropic and the concomitant use of two or more benzodiazepines are related to an increased risk of fractures in old age. However, also controversial results exist. The aim was to describe associations between the use of a psychotropic drug, or the concomitant use of two or more of these drugs and the risk of fractures in a population aged 65 years or over. Methods: This study was a part of a prospective longitudinal population-based study carried out in the municipality of Lieto, South-Western Finland. The objective was to describe gender-specific associations between the use of one psychotropic drug [benzodiazepine (BZD), antipsychotic (AP) or antidepressant (AD)] or the concomitant use of two or more psychotropic drugs and the risk of fractures in a population 65 years or over. Subjects were participants in the first wave of the Lieto study in 1990-1991, and they were followed up until the end of 1996. Information about fractures confirmed with radiology reports in 1,177 subjects (482 men and 695 women) during the follow-up was collected from medical records. Two follow-up periods (three and six years) were used, and previously found risk factors of fractures were adjusted as confounding factors separately for men and women. The Poisson regression model was used in the analyses. Results: The concomitant use of