pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma morphometric and immunohistochemical analysis of six autopsy cases肺肿瘤血栓性微血管病引起胃癌形态学和免疫组织化学分析,六个尸检病例.pdfVIP

Okubo et al. Diagnostic Pathology 2011, 6:27 /content/6/1/27 RESEARCH Open Access Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: Morphometric and immunohistochemical analysis of six autopsy cases 1 1 1 1* 2 3 Yoichiro Okubo , Megumi Wakayama , Kanako Kitahara , Tetsuo Nemoto , Tomoyuki Yokose , Fumihito Abe , 1 1 1 4 1 1 Nobuyuki Hiruta , Daisuke Sasai , Minoru Shinozaki , Haruo Nakayama , Takao Ishiwatari and Kazutoshi Shibuya Abstract Background: Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer- related pulmonary complication. However, the pathogenesis and pathophysiology of this debilitating condition still remains obscure and no effective management was recommended. The present study aims to elucidate the pathophysiology of PTTM. Methods: Autopsy records were searched to extract cases of pulmonary tumor embolism induced by metastasis of gastric carcinoma in the Toho University Omori Medical Center from 2000 to 2006. And then, tissue sections of extracted cases were prepared for not only light microscopic observation but morphometric analysis with the use of selected PTTM cases. Results: Six autopsies involved PTTM and clinicopathological data of them were summarized. There was a significant negative association between pulmonary arterial diameter and stenosis rate in four cases. Although all cases showed an increase of stenosis rate to some degree, the degree of stenosis rate varied from case to case. Significant differences were found for average ste