reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones and oximesnitrilimines反应和联氨腈氧化物,腙和肟.pdfVIP

Molecules 2005, 10, 492-507 molecules ISSN 1420-3049 Review Reaction of Nitrilimines and Nitrile Oxides with Hydrazines, Hydrazones and Oximes Abdel-Rahman S. Ferwanah 1 and Adel M. Awadallah 2,* 1 Chemistry Department, Faculty of Science, Al-Azhar University of Gaza, P.O. Box-1277, Gaza, Palestine. Fax: (+970) 8-2823180, E-mail: ferwanah@ 2 Chemistry Department, Faculty of Science, Islamic University of Gaza, P.O. Box-108, Gaza, Palestine. Fax: (+970) 8-2823310 * Author to whom correspondence should be addressed; e-mail: awada@ Received: 18 May 2004; in revised form: 28 December 2004 / Accepted: 29 December 2004 / Published: 28 February 2005 __________________________________________________________________________________ Abstract: This review article discusses the reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones, and oximes. Three reaction modes were observed. The article mainly covers our work published over the last fifteen years, in which interesting heterocyles such as oxadiazoles, triazoles, and tetrazines were synthesized and fully characterized. Keywords: Nitrilimines, nitrile Oxides, hydrazines, hydrazones, oximes. __________________________________________________________________________________ Introduction The concept of 1,3-dipoles was first introduced by Huisgen in 1963 [1]. Since that time, a lot of work has been done on their reactions and the mechanism of 1,3-dipolar cycloaddition. A comprehensive review