reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings protection by methanolic extracts of phoebe grandis活性氧种群生态学endothelium-dependent减损风头methanolic提取物在大鼠主动脉环保护的菲比.pdfVIP

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reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings protection by methanolic extracts of phoebe grandis活性氧种群生态学endothelium-dependent减损风头methanolic提取物在大鼠主动脉环保护的菲比.pdf

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reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings protection by methanolic extracts of phoebe grandis活性氧种群生态学endothelium-dependent减损风头methanolic提取物在大鼠主动脉环保护的菲比

Molecules 2011, 16, 2990-3000; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Reactive Oxygen Species-Induced Impairment of Endothelium- Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis 1 1 2 1 Lau Yeh-Siang , Gopal Subramaniam , A. Hamid A. Hadi , Dharmani Murugan and Mohd Rais Mustafa 1,* 1 Centre of Natural Products and Drug Discovery (CENAR), Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: lauyehsiang@ (L.Y.-S.); kadagam@ (G.S.); dharmani79@.my (D.M.) 2 Centre of Natural Products and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: ahamid@.my * Author to whom correspondence should be addressed; E-Mail: rais@.my; Fax: 603 Received: 10 February 2011; in revised form: 15 March 2011 / Accepted: 1 April 2011 / Published: 6 April 2011 Abstract: Generation of reactive oxygen species plays a pivotal role in the development of cardiovascular diseases. The present study describes the effects of the methanolic extract of Phoebe grandis (MPG) stem bark on reactive oxygen species-induced endothelial dysfunction in vitro. Endothelium-dependent (acetylcholine, ACh) and -independent relaxation (sodium nitroprusside, SNP) was investigated from isola