原创力文档pulmonary haptoglobin (php) is part of the surfactant system in the human lung肺结合珠蛋白(php)是人类肺表面活性剂体系的一部分.pdfVIP
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pulmonary haptoglobin (php) is part of the surfactant system in the human lung肺结合珠蛋白(php)是人类肺表面活性剂体系的一部分
Abdullah and Goldmann Diagnostic Pathology 2012, 7:158
/content/7/1/158
RESEARCH Open Access
Pulmonary haptoglobin (pHp) is part of the
surfactant system in the human lung
*
Mahdi Abdullah and Torsten Goldmann
Abstract: Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor
CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as
the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs
further. Here we show, by means of confocal microscopy and immune-electron-microscopy, a clear co-localization
of pHp with Surfactant protein-B in lamellar bodies of Alveolar Epithelial Cells Type II. These results are underlined
by immunohistochemical stainings in differently fixed human lung tissues, which show pHp in vesicular and
released form. The images of the released form resemble the intended position of surfactant in the human alveolus.
pHp is secreted by Alveolar epithelial cells type II as previously shown. Moreover, pHp is co-localized with
Surfactant protein-B. We conclude that the presented data shows that pHp is a native part of the surfactant system
in the human lung.
Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912.
Keywords: Haptoglobin, Lung, Surfactant, Protein
Background after ten minutes of stimulation, which is by far faster
We recently reported that the plasma protein haptoglo- than the most other immuno-regulatory systems in the
bin (Hp) is also synthesized and expressed in the human lung e.g. Toll-like receptor mediated signaling. It has
lung [1]. W
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