real time imaging of biomarkers in the parkinsons brain using mini-implantable biosensors. ii. pharmaceutical therapy with bromocriptine实时成像帕金森脑使用mini-implantable生物标志物的生物传感器。.pdfVIP
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real time imaging of biomarkers in the parkinsons brain using mini-implantable biosensors. ii. pharmaceutical therapy with bromocriptine实时成像帕金森脑使用mini-implantable生物标志物的生物传感器。
Pharmaceuticals 2009, 2, 236-249; doi:10.3390/ph2030236
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Article
Real Time Imaging of Biomarkers in the Parkinsons Brain
Using Mini-Implantable Biosensors. II. Pharmaceutical Therapy
with Bromocriptine
Patricia A. Broderick 1,2,3,* and Edwin H. Kolodny 3
1 Department of Physiology Pharmacology, Sophie Davis Sch. Biomed. Edu., CCNY, New York,
NY 10031, USA
2 Departments of Biology, Psychology, CUNY Grad. Sch., New York, NY 10031, USA
3 Department of Neurology, NYU Sch. Med., Langone Med. Ctr., NYU Langone Comprehensive
Epilepsy Ctr., New York, NY 10016, USA
* Author to whom correspondence should be addressed; E-Mail: drpabroderick@;
Tel.: +1-718-928-4858.
Received: 27 October 2009; in revised form: 12 December 2009 / Accepted: 16 December 2009 /
Published: 22 December 2009
Abstract: We used Neuromolecular Imaging (NMI) and trademarked BRODERICK
PROBE® mini-implantable biosensors, to selectively and separately detect neuro-
transmitters in vivo, on line, within seconds in the dorsal striatal brain of the Parkinson’s
Disease (PD) animal model. We directly compared our results derived from PD to the
normal striatal brain of the non-Parkinson’s Disease (non-PD) animal. This advanced
biotechnology enabled the imaging of dopamine (DA), serotonin (5-HT), homovanillic
acid (HVA) a metabolite of DA, L-tryptophan (L-TP) a precursor to 5-HT and peptides,
dynorphin A 1-17
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