rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of hiv反弹后的残余血浆病毒血症初始下降后静脉注射免疫球蛋白与有效的抗逆转录病毒治疗的艾滋病毒.pdfVIP

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rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of hiv反弹后的残余血浆病毒血症初始下降后静脉注射免疫球蛋白与有效的抗逆转录病毒治疗的艾滋病毒.pdf

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rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of hiv反弹后的残余血浆病毒血症初始下降后静脉注射免疫球蛋白与有效的抗逆转录病毒治疗的艾滋病毒

Mellberg et al. AIDS Research and Therapy 2011, 8:21 /content/8/1/21 RESEARCH Open Access Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV 1* 2 3 1 3,4 Tomas Mellberg , Veronica D Gonzalez , Annica Lindkvist , Arvid Edén , Anders Sönnerborg , 2 5 1 Johan K Sandberg , Bo Svennerholm and Magnus Gisslén Abstract Background: High dosage of intravenous immunoglobulin (IVIG) has been observed as a possible activator of HIV gene expression in latently infected resting CD4+ T-cells, leading to a substantial decrease in both the reservoir and the residual plasma viremia when added to effective ART. IVIG treatment has also been reported to expand T regulatory cells (Tregs). The aim of this study was to evaluate possible long-term effect of IVIG treatment on residual viremia and T-lymphocyte activation. Methods: Nine HIV-infected subjects on effective ART included in a previously reported study on IVIG treatment were evaluated 48-104 weeks after therapy. In addition, 14 HIV-infected controls on suppressive ART were included. HIV-1 RNA was analyzed in cell-free plasma by using an ultrasensitive PCR-method with a detection limit of 2 copies/mL. T-lymphocyte activation markers and serum interleukins were measured. Results: Plasma residual viremia rebounded to pre-treatment levels, 48-104 weeks after the initial decrease that was observed following treatment with high-dosage IVIG. No long-term effect was observed regarding T- lymphocyte activation markers, T-regulatory cells or serum interleukins. In a post-hoc anal