recent advances in intracellular and in vivo ros sensing focus on nanoparticle and nanotube applications细胞内的最近进展和体内活性氧传感关注纳米颗粒和纳米管的应用.pdfVIP

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recent advances in intracellular and in vivo ros sensing focus on nanoparticle and nanotube applications细胞内的最近进展和体内活性氧传感关注纳米颗粒和纳米管的应用.pdf

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recent advances in intracellular and in vivo ros sensing focus on nanoparticle and nanotube applications细胞内的最近进展和体内活性氧传感关注纳米颗粒和纳米管的应用

Int. J. Mol. Sci. 2012, 13, 10660-10679; doi:10.3390/ijms130910660 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Recent Advances in Intracellular and In Vivo ROS Sensing: Focus on Nanoparticle and Nanotube Applications Larissa M. Uusitalo and Nadine Hempel * Nanobioscience Constellation, College of Nanoscale Sciences Engineering, University at Albany, SUNY, 257 Fuller Rd., Albany, NY 12203, USA; E-Mail: luusitalo@ * Author to whom correspondence should be addressed; E-Mail: nhempel@; Tel.: +1-518-956-7309; Fax: +1-518-437-8687. Received: 2 July 2012; in revised form: 2 August 2012 / Accepted: 16 August 2012 / Published: 24 August 2012 Abstract: Reactive oxygen species (ROS) are increasingly being implicated in the regulation of cellular signaling cascades. Intracellular ROS fluxes are associated with cellular function ranging from proliferation to cell death. Moreover, the importance of subtle, spatio-temporal shifts in ROS during localized cellular signaling events is being realized. Understanding the biochemical nature of the ROS involved will enhance our knowledge of redox-signaling. An ideal intracellular sensor should therefore resolve real-time, localized ROS changes, be highly sensitive to physiologically relevant shifts in ROS and provide specificity towards a pa