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recent developments in the immunobiology of rheumatoid arthritis风湿性关节炎的免疫生物学的最新发展
Available online /content/10/2/204
Review
Recent developments in the immunobiology of rheumatoid
arthritis
Anna K Andersson, Ching Li and Fionula M Brennan
Kennedy Institute of Rheumatology, Imperial College Faculty of Medicine, 1 Aspenlea Road, London W6 8LH, UK
Corresponding author: Anna Andersson, a.andersson@imperial.ac.uk
Published: 14 March 2008 Arthritis Research Therapy 2008, 10:204 (doi:10.1186/ar2370)
This article is online at /content/10/2/204
© 2008 BioMed Central Ltd
Abstract In the present review we look at recent developments in the
Progress into the understanding of immunopathology in rheumatoid immunobiology of RA, with focus on the role of T cells and
arthritis is reviewed in the present article with regard to pro- B cells, the products they produce, including cytokines and
inflammatory cytokine production, cell activation and recruitment, autoantibodies, and the genetic factors potentially involved in
and osteoclastogenesis. Studies highlight the potential importance their regulation and function.
of T helper 17 cells and regulatory T cells in driving and suppres-
sing inflammation in rheumatoid arthritis, respectively, and highlight T cells
other potential T-cell therapeutic targets. The genetic associations
of the HLA shared epitope alleles with antibodies to citrullinated In contrast to the clearly defined role of macrophage-derived
peptides in rheumatoid arthritis patients indicate that T cells are cytokines such as TNFα in the pathogenesis of RA, the
providing help to B cells to produce autoantibodies, and there is relevance an
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