reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus减少astrogliosis和microgliosis脑脊液分流的实验性脑积水.pdfVIP

Cerebrospinal Fluid Research BioMed Central Research Open Access Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus Janet M Miller*1,2,4 and James P McAllister II 1,2,3,4 Address: 1Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA, 2Department of Physiology, Wayne State University, Detroit, Michigan, USA, 3Department of Anatomy and Cell Biology, Wayne State University, Detroit Michigan, USA and 4Department of Pediatric Neurosurgery, Childrens Hospital of Michigan, Detroit, Michigan USA Email: Janet M Miller* - janetmiller1999@; James P McAllister II - pmcallister@ * Corresponding author Published: 7 June 2007 Received: 19 September 2006 Accepted: 7 June 2007 Cerebrospinal Fluid Research 2007, 4:5 doi:10.1186/1743-8454-4-5 This article is available from: /content/4/1/5 © 2007 Miller and McAllister II; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Reactive gliosis has the potential to alter biomechanical properties of the brain, impede neuronal regeneration and affect plasticity. Determining the onset and progression of reactive astrogliosis and microgliosis due to hydrocephalus is important for designing better clinical treatments. Methods: Reactive astrogliosis and microgliosis were