原创力文档regeneration of the immunoglobulin heavy-chain repertoire after transient b-cell depletion with an anti-cd20 antibody再生后的免疫球蛋白重链曲目瞬态b细胞耗竭anti-cd20抗体.pdfVIP
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regeneration of the immunoglobulin heavy-chain repertoire after transient b-cell depletion with an anti-cd20 antibody再生后的免疫球蛋白重链曲目瞬态b细胞耗竭anti-cd20抗体
Available online /content/7/4/R714
Vol 7 No 4 Open Access
Research article
Regeneration of the immunoglobulin heavy-chain repertoire after
transient B-cell depletion with an anti-CD20 antibody
1 1 1 2
Anne-Sophie Rouzière , Christian Kneitz , Arumugam Palanichamy , Thomas Dörner and Hans-
Peter Tony1
1Department of Medicine II, Rheumatology and Clinical Immunology, University of Wuerzburg, Germany
2Charité University Hospital, Berlin, Germany
Corresponding author: Hans-Peter Tony, Tony_H@medizin.uni-wuerzburg.de
Received: 5 Aug 2004 Revisions requested: 10 Sep 2004 Revisions received: 1 Mar 2005 Accepted: 7 Mar 2005 Published: 1 Apr 2005
Arthritis Research Therapy 2005, 7:R714-R724 (DOI 10.1186/ar1731)
This article is online at: /content/7/4/R714
© 2005 Rouzière et al, licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited.
Abstract
B-cell depletive therapies have beneficial effects in patients and recirculation of a highly mutated B-cell population. These
suffering from rheumatoid arthritis. Nevertheless, the role of B cells expressed very different Ig-VH genes. They were class-
cells in the pathogenesis of the disease is not clear. In particular, switched and could be detected for a short period only. Patient
it is not known how the regeneration of the B-cell repertoire A was followed long term, whereb
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