regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis区域的评估关节软骨基因表达和小蛋白多糖代谢在骨关节炎的动物模型.pdfVIP

Available online /content/7/4/R852 Vol 7 No 4 Open Access Research article Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis 1 1 1 2 1 Allan A Young , Margaret M Smith , Susan M Smith , Martin A Cake , Peter Ghosh , 2 1 1 3 Richard A Read , James Melrose , David H Sonnabend , Peter J Roughley and Christopher B Little1 1Raymond Purves Research Laboratory, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia 2School of Veterinary and Biomedical Sciences, Murdoch University, Perth, Western Australia, Australia 3Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada Corresponding author: Allan A Young, al_young@ Received: 23 Jan 2005 Revisions requested: 16 Feb 2005 Revisions received: 9 Apr 2005 Accepted: 14 Apr 2005 Published: 12 May 2005 Arthritis Research Therapy 2005, 7:R852-R861 (DOI 10.1186/ar1756) This article is online at: /content/7/4/R852 © 2005 Young et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Osteoarthritis (OA), the commonest form of arthritis and a major was observed. In this region there was significant upregulation cause of morbidity, is cha