原创力文档relationship between tumor dna methylation status and patient characteristics in african-american and european-american women with breast cancer肿瘤dna甲基化状态与病人之间的关系特征在非洲裔美国人和欧美患有乳腺癌的妇女.pdfVIP
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relationship between tumor dna methylation status and patient characteristics in african-american and european-american women with breast cancer肿瘤dna甲基化状态与病人之间的关系特征在非洲裔美国人和欧美患有乳腺癌的妇女
Relationship between Tumor DNA Methylation Status
and Patient Characteristics in African-American and
European-American Women with Breast Cancer
1 2 2 3 2
Songping Wang , Tiffany H. Dorsey , Atsushi Terunuma , Rick A. Kittles , Stefan Ambs , Bernard Kwabi-
Addo1*
1 Department of Biochemistry and Molecular Biology, Howard University, Washington, D.C., United States of America, 2 Laboratory of Human Carcinogenesis, Center of
Cancer Research and Epidemiology and Genetics Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America,
3 Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
Abstract
Aberrant DNA methylation is critical for development and progression of breast cancer. We investigated the association of
CpG island methylation in candidate genes and clinicopathological features in 65 African-American (AA) and European-
American (EA) breast cancer patients. Quantitative methylation analysis was carried out on bisulfite modified genomic DNA
and sequencing (pyrosequencing) for promoter CpG islands of p 16, ESR1, RASSF1A, RARb2, CDH13, HIN1, SFRP 1 genes and
the LINE1 repetitive element using matched paired non-cancerous and breast tumor specimen (32 AA and 33 EA women).
Five of the genes, all known tumor suppressor genes (RASSF1A, RARb2, CDH13, HIN1 and SFRP 1), were found to be
frequently hypermethylated in breast tumor tissues but not in the adjacent non-cancerous tissues. Significant differences in
the CDH13 methylation status were observed by comparing DNA methylation between AA and EA patients, with more
obvious CDH13 methylation differences between
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