原创力文档relationship of epstein-barr virus and interleukin 10 promoter polymorphisms with the risk and clinical outcome of childhood burkitt lymphoma巴尔病毒关系和白介素10启动子多态性与儿童伯基特淋巴瘤的风险和临床结果.pdfVIP
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relationship of epstein-barr virus and interleukin 10 promoter polymorphisms with the risk and clinical outcome of childhood burkitt lymphoma巴尔病毒关系和白介素10启动子多态性与儿童伯基特淋巴瘤的风险和临床结果
Relationship of Epstein-Barr Virus and Interleukin 10
Promoter Polymorphisms with the Risk and Clinical
Outcome of Childhood Burkitt Lymphoma
1 ´ 1 2 ´ 3 1
Carolina Minnicelli , Mario H. M. Barros , Claudete E. Klumb , Sergio O. Romano , Ilana R. Zalcberg ,
Rocio Hassan1*
ˆ ˆ
1 Bone Marrow Transplantation Center (CEMO), Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil, 2 Hematology Service, Instituto Nacional de Cancer (INCA), Rio
ˆ
de Janeiro, Brazil, 3 Pathology Department (DIPAT), Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil
Abstract
Epstein-Barr virus (EBV) is an important environmental factor associated to the development of Burkitt lymphoma (BL) in
endemic and intermediate risk regions. However, little is known about the contribution of genetic constitution to the
development and clinical response of the disease. The aim of this work was to investigate the role of EBV and Interleukin 10
(IL10) single nucleotide polymorphisms ( 21082A/G, 2819C/T, 2592C/A) and microsatellites (IL10.R and IL10.G) in
susceptibility and clinical outcome in pediatric BL patients, in a region with intermediate EBV association frequency. The
frequencies of IL10 promoter Single nucleotide polymorphisms 21082A/G, 2819C/T, 2592C/A, and IL10.R and IL10.G
microsatellites were compared in 62 pediatric patients and 216
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