relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study牙齿脱落的关系从fujiwara-kyo轻度记忆障碍和认知障碍的发现研究.pdfVIP

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relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study牙齿脱落的关系从fujiwara-kyo轻度记忆障碍和认知障碍的发现研究.pdf

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relationship of tooth loss to mild memory impairment and cognitive impairment findings from the fujiwara-kyo study牙齿脱落的关系从fujiwara-kyo轻度记忆障碍和认知障碍的发现研究

Okamoto et al. Behavioral and Brain Functions 2010, 6:77 /content/6/1/77 RESEARCH Open Access Relationship of tooth loss to mild memory impairment and cognitive impairment: findings from the fujiwara-kyo study 1* 2,3 4,5 1 6 1 Nozomi Okamoto , Masayuki Morikawa , Kensuke Okamoto , Noboru Habu , Junko Iwamoto , Kimiko Tomioka , 1 7 7 1 Keigo Saeki , Motokazu Yanagi , Nobuko Amano , Norio Kurumatani Abstract Background: This cross-sectional study investigated the relationship between the number of remaining teeth to mild memory impairment (MMI), which is a preclinical stage of dementia, and to cognitive impairment. Methods: The subjects were aged 65 years or older and were grouped according to their score for the Mini- Mental State Examination (MMSE), the three-word delayed recall test in the MMSE, and the Geriatric Depression Scale into the control group (n = 3,696), the MMI group (n = 121), and the low MMSE score (23 or lower) group (n = 214). We collected data on the number of remaining teeth, the length of the edentulous period, health- related lifestyle, medical history, blood pressure, height, and body weight. Fasting venous blood samples were also obtained. Results: Multiple logistic regression analysis, adjusted for depressive symptoms, age, sex, length of education, and other explanatory variables, revealed that the odds ratios of 0-10 remaining teeth to 22-32 remaining teeth were 1.679 (95% CI 1.073-2.627) for MMI and 2.177 (95% CI 1.510-3.140) for a low MMSE score. A significant relationship was also found between the length of the edentulous period and the risk of a low MMSE score