remission in schizophrenia results of cross-sectional with 6-month follow-up period and 1-year observational therapeutic studies in an outpatient population缓解精神分裂症的横断面和6个月随访期间1年观察门诊治疗研究人口.pdfVIP

Mosolov et al. Annals of General Psychiatry 2012, 11:1 /content/11/1/1 PRIMARY RESEARCH Open Access Remission in schizophrenia: results of cross- sectional with 6-month follow-up period and 1-year observational therapeutic studies in an outpatient population Sergey N Mosolov1*, Andrey V Potapov1 and Uriy V Ushakov2 Abstract Background: A standardized definition of remission criteria in schizophrenia was proposed by the International group of NC Andreasen in 2005 (low symptom threshold for the eight core Positive and Negative Syndrome Scale (PANSS) symptoms for at least 6 consecutive months). Methods: A cross-sectional study of remission rate, using a 6-month follow-up to assess symptomatic stability, was conducted in two healthcare districts (first and second) of an outpatient psychiatric service in Moscow. The key inclusion criteria were outpatients with an International Classification of Diseases, 10th edition (ICD-10) diagnosis of schizophrenia or schizoaffective disorder. Remission was assessed using modern criteria (severity and time criteria), PANSS and Global Assessment of Functioning (GAF). Patients who were stable but did not satisfied the symptomatic criteria were included in a further 1-year observational study, with the first group (first district) receiving risperidone (long-acting, injectable) (RLAI) and the second group (second district) continuing to receiving routine treatment. Symptoms were assessed with PANSS, social functioning with the personal and social performance scale, compliance with rating of medication influences scale, and extrapyramidal side effects with the Simpson-Angus scale. Results: Only 64 (31.5%) of 203 outpatients met the criteria for symptomatic remission in the cross-sectional study, but at the end of the 6-month follow-up period, 158 (77.8%) were stable (irrespective of