原创力文档replication of norovirus in cell culture reveals a tropism for dendritic cells and macrophages复制诺瓦克病毒在细胞培养中揭示了树突状细胞和巨噬细胞的趋向性.pdfVIP
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replication of norovirus in cell culture reveals a tropism for dendritic cells and macrophages复制诺瓦克病毒在细胞培养中揭示了树突状细胞和巨噬细胞的趋向性
Open access, freely available online PLoS BIOLOGY
Replication of Norovirus in Cell Culture
Reveals a Tropism
for Dendritic Cells and Macrophages
1 1 1 2 2
Christiane E. Wobus , Stephanie M. Karst , Larissa B. Thackray , Kyeong-Ok Chang , Stanislav V. Sosnovtsev ,
¨ 2 1¤ 3 2 1*
Gael Belliot , Anne Krug , Jason M. Mackenzie , Kim Y. Green , Herbert W. Virgin IV
1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Laboratory of Infectious Diseases,
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America,
3 Sir Albert Sakzewski Virus Research Centre, Royal Children’s Hospital, and Clinical Medical Virology Centre, University of Queensland, Brisbane, Australia
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found
that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary
dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-ab receptor and STAT-1, and was
associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein
of serially passaged MNV-1 was associated with virulence attenuation in vivo. This is the first report of replication of a
norovirus in cell culture. The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism
of a norovirus for cells of the hematopoietic linea
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