原创力文档risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers a case-control study关节置换术感染的危险因素患者肿瘤坏死因子α-blockers病例对照研究.pdfVIP
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risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers a case-control study关节置换术感染的危险因素患者肿瘤坏死因子α-blockers病例对照研究
Gilson et al. Arthritis Research Therapy 2010, 12:R145
/content/12/4/R145
RESEARCH ARTICLE Open Access
Risk factors for total joint arthroplasty infection
in patients receiving tumor necrosis factor
a-blockers: a case-control study
1* 1 2 3 4 5
Mélanie Gilson , Laure Gossec , Xavier Mariette , Dalenda Gherissi , Marie-Hélène Guyot , Jean-Marie Berthelot ,
Daniel Wendling6 7 8 9 1
, Christian Michelet , Pierre Dellamonica , Florence Tubach , Maxime Dougados ,
Dominique Salmon3
Abstract
Introduction: The objective of this study was to assess natural microbial agents, history and risk factors for total
joint arthroplasty (TJA) infections in patients receiving tumor necrosis factor (TNF)a-blockers, through the French
RATIO registry and a case-control study.
Methods: Cases were TJA infections during TNFa-blocker treatments. Each case was compared to two controls
(with TJA and TNFa-blocker therapy, but without TJA infection) matched on age (±15 years), TJA localization, type
of rheumatic disorder and disease duration (±15 years). Statistical analyses included univariate and multivariate
analyses with conditional logistic regression.
Results: In the 20 cases (18 rheumatoid arthritis), TJA infection concerned principally the knee (n = 12, 60%) and
the hip (n = 5, 25%). Staphylococcus was the more frequent microorganism involved (n = 15, 75%). Four patients
(20%) were hospitalized in an intensive care unit and two died from infection. Eight cases (40%) versus 5 controls
(13%) had undergone primary TJA or TJA revision for the joint subsequently infected during the last year (P =
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