risk of prostate cancer after trans urethral resection of bph a cohort and nested case-control study反式尿道切除术后前列腺癌的风险bph组和嵌套病例对照研究.pdfVIP
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risk of prostate cancer after trans urethral resection of bph a cohort and nested case-control study反式尿道切除术后前列腺癌的风险bph组和嵌套病例对照研究
Cancers 2011, 3, 4127-4138; doi:10.3390/cancers3044127
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Article
Risk of Prostate Cancer after Trans Urethral Resection of BPH:
A Cohort and Nested Case-Control Study
Camilla T. Karlsson 1,*, Fredrik Wiklund 2, Henrik Grönberg 2, Anders Bergh 3 and
1
Beatrice Melin
1 Department of Radiation Sciences, Oncology, Umeå University, SE-901 87 Umeå, Sweden;
E-Mail: beatrice.melin@onkologi.umu.se
2 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 77,
Sweden; E-Mails: fredrik.wiklund@meb.ki.se (F.W.); henrik.gronberg@meb.ki.se (H.G.)
3 Department of Medical Biosciences, Pathology, Umeå University, SE-901 87 Umeå, Sweden;
E-Mail: anders.bergh@medbio.umu.se
* Author to whom correspondence should be addressed; E-Mail: Camilla.thellenberg@onkologi.umu.se;
Tel.: +46-9078583296; Fax: +46
Received: 14 September 2011; in revised form: 24 October 2011 / Accepted: 28 October 2011 /
Published: 8 November 2011
Abstract: Epidemiological and experimental evidence suggests that inflammation plays a
role in both prostate cancer (PCa) and benign prostate hyperplasia (BPH). This study
evaluates the risk of PC after transurethral resection (TURP) for BPH and estimates the
PCa risk related to presence of inflammation in the resected material. The Pathology
Department at the University Hospital of Umeå (Umeå, Sweden) identified BPH
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