rna sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to micerna序列揭示了微分表达式的线粒体氧化还原基因长寿裸鼢鼠相比,老鼠.pdfVIP

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2017-09-11 发布于上海
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rna sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to micerna序列揭示了微分表达式的线粒体氧化还原基因长寿裸鼢鼠相比,老鼠.pdf

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rna sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to micerna序列揭示了微分表达式的线粒体氧化还原基因长寿裸鼢鼠相比,老鼠

RNA Sequencing Reveals Differential Expression of Mitochondrial and Oxidation Reduction Genes in the Long-Lived Naked Mole-Rat When Compared to Mice 1. 2. 2 3 4 5 Chuanfei Yu , Yang Li , Andrew Holmes , Karol Szafranski , Chris G. Faulkes , Clive W. Coen , 6 3 ˜ ˜ 2 1 Rochelle Buffenstein , Matthias Platzer , Joao Pedro de Magalhaes * , George M. Church 1 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, 3 Fritz Lipmann Institute – Leibniz Institute for Age Research, Jena, Germany, 4 School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom, 5 Reproductive Neurobiology and Early Life Origins of Disease, Division of Women’s Health, King’s College London, London, United Kingdom, 6 Barshop Institute for Aging and Longevity Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America Abstract The naked mole-rat (Heterocephalus glaber) is a long-lived, cancer resistant rodent and there is a great interest in identifying the adaptations responsible for these and other of its unique traits. We employed RNA sequencing to compare liver gene expression profiles between naked mole-rats and wild-derived mice. Our results indicate that genes associated with oxidoreduction and mitochondria were expressed at higher relative levels in naked mole-rats. The largest effect is nearly 300-