原创力文档rnai in arthropods insight into the machinery and applications for understanding the pathogen-vector interfacernai节肢动物洞察的机械和理解pathogen-vector申请界面.pdfVIP
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rnai in arthropods insight into the machinery and applications for understanding the pathogen-vector interfacernai节肢动物洞察的机械和理解pathogen-vector申请界面
Genes 2012, 3, 702-741; doi:10.3390/genes3040702
OPEN ACCESS
genes
ISSN 2073-4425
/journal/genes
Review
RNAi in Arthropods: Insight into the Machinery and
Applications for Understanding the Pathogen-Vector Interface
1 2 3 1
Annette-Christi Barnard , Ard M. Nijhof , Wilma Fick , Christian Stutzer and
Christine Maritz-Olivier 3,*
1 Department of Biochemistry, University of Pretoria, Pretoria, 0002, South Africa;
E-Mails: annettechristi@ (A.C.B.); christian.stutzer@ (C.S.)
2 Institut für Parasitologie und Tropenveterinärmedizin, Freie Universität Berlin, Königsweg 67,
14163, Berlin, Germany; E-Mail: ardmenzo.nijhof@fu-berlin.de
3 Department of Genetics, University of Pretoria, Pretoria, 0002, South Africa;
E-Mail: wilma.fick@up.ac.za
* Author to whom correspondence should be addressed; E-Mail: christine.maritz@up.ac.za;
Tel.: +27-012-420-3945; Fax: +27-012-362-5327.
Received: 3 September 2012; in revised form: 19 October 2012 / Accepted: 23 October 2012 /
Published: 6 November 2012
Abstract: The availability of genome sequencing data in combination with knowledge of
expressed genes via transcriptome and proteome data has greatly advanced our
understanding of arthropod vectors of disease. Not only have we gained insight into vector
biology, but also into their respective vector-pathogen interactions. By combining the
strengths of postgenomic datab
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