原创力文档role of androgen receptor cag repeat polymorphism and x-inactivation in the manifestation of recurrent spontaneous abortions in indian women雄激素受体的作用cag重复多态性和x-inactivation在印度女性复发性自然流产的表现.pdfVIP
- 1、本文档共7页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
role of androgen receptor cag repeat polymorphism and x-inactivation in the manifestation of recurrent spontaneous abortions in indian women雄激素受体的作用cag重复多态性和x-inactivation在印度女性复发性自然流产的表现
Role of Androgen Receptor CAG Repeat Polymorphism
and X-Inactivation in the Manifestation of Recurrent
Spontaneous Abortions in Indian Women
1 1 1 2
Meka Aruna , Shilpi Dasgupta , Pisapati V. S. Sirisha , Sadaranga Andal Bhaskar , Surapaneni
3 4 1
Tarakeswari , Lalji Singh , B. Mohan Reddy *
1 Molecular Anthropology Group, Biological Anthropology Unit, Indian Statistical Institute, Habsiguda, Hyderabad, India, 2 Lakshmi Fertility Clinic and Research Centre,
Pogathota, Nellore, Andhra Pradesh, India, 3 Fernandez Hospital, Hyderabad, India, 4 Centre for Cellular and Molecular Biology, Hyderabad, India
Abstract
The aim of the present study was to investigate the role of CAG repeat polymorphism and X-chromosome Inactivation (XCI)
pattern in Recurrent Spontaneous Abortions among Indian women which has not been hitherto explored. 117 RSA cases
and 224 Controls were included in the study. Cases were recruited from two different hospitals - Lakshmi Fertility Clinic,
Nellore and Fernandez Maternity Hospital, Hyderabad. Controls were roughly matched for age, ethnicity and socioeconomic
status. The CAG repeats of the Androgen Receptor gene were genotyped using a PCR-based assay and were analysed using
the GeneMapper software to determine the CAG repeat length. XCI analysis was also carried out to assess the inactivation
percentages. RSA cases had a significantly greater frequency of allele sizes in the polymorphic range above 19 repeats
(p = 0.006), which is the median value of the controls, and in the biallelic mean range above 21 repeats (p = 0.002). We found
no evidence of abnormal incidence of skewed X-inactivation. We conclude that longer CAG repeat lengths are associated
with increased odds for
您可能关注的文档
- review and standardization of cell phone exposure calculations using the sam phantom and anatomically correct head models审查和手机接触计算的标准化使用sam幻影和解剖学上正确的模型.pdf
- reverse-engineering the arabidopsis thaliana transcriptional network under changing environmental conditions逆向工程在不断变化的环境条件下拟南芥转录网络.pdf
- review of dc system technologies for large scale integration of wind energy systems with electricity grids对直流系统技术大规模风力发电系统与电网的集成.pdf
- review and classification of variability analysis techniques with clinical applications审查和分类的可变性分析技术与临床应用.pdf
- review of histopathological and molecular prognostic features in colorectal cancer评审的组织病理学和分子结直肠癌的预后特征.pdf
- review of biomedical image processing回顾生物医学图像处理.pdf
- review of pesticide urinary biomarker measurements from selected us epa children’s observational exposure studies评估农药尿生物标记测量选择美国epa接触孩子的观察研究.pdf
- review of random phase encoding in volume holographic storage审查的随机相位编码在体全息存储.pdf
- review of the application of modern cytogenetic methods (fishgish) to the study of reticulation (polyploidyhybridisation)回顾现代细胞遗传学方法(fishgish)的应用研究网状(polyploidyhybridisation).pdf
- review of the evidence base for ecosystem-based approaches for adaptation to climate change审查的证据基础生态系统适应气候变化的方法.pdf
文档评论（0）