原创力文档role of microglia in oxidative toxicity associated with encephalomycarditis virus infection in the central nervous system小胶质细胞在氧化毒性中的作用与encephalomycarditis在中枢神经系统病毒感染.pdfVIP
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role of microglia in oxidative toxicity associated with encephalomycarditis virus infection in the central nervous system小胶质细胞在氧化毒性中的作用与encephalomycarditis在中枢神经系统病毒感染
Int. J. Mol. Sci. 2012, 13, 7365-7374; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Role of Microglia in Oxidative Toxicity Associated with
Encephalomycarditis Virus Infection in the Central
Nervous System
Yasuhisa Ano 1, Akikazu Sakudo 2 and Takashi Onodera 3,*
1 Central Laboratories for Frontier Technology, Kirin Holdings Co, Ltd, 1-13-5 Fukuura
Kanazawa-ku, Yokohama-shi, Kanagawa 236-0004, Japan; E-Mail: Yasuhisa_Ano@kirin.co.jp
2 Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine,
University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan;
E-Mail: sakudo@med.u-ryukyu.ac.jp
3 Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi,
Bunkyo-ku, Tokyo 113-8657, Japan
* Author to whom correspondence should be addressed; E-Mail: aonoder@mail.ecc.u-tokyo.ac.jp;
Tel.: +81-03-5841-5389; Fax: +81-03-5841-5389.
Received: 2 May 2012; in revised form: 28 May 2012 / Accepted: 5 June 2012 /
Published: 14 June 2012
Abstract: The single-stranded RNA encephalomyocarditis virus (EMCV) can replicate in
the central nervous system (CNS) and lead to prominent brain lesions in the stratum
pyramidale hippocampus and the stratum granulosum cerebelli. Activated microglia cells
infected by EMCV produce a massive burst of reactive oxygen species (ROS) via NADPH
oxidase 2 (NOX2) activation, leading to neur
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