role of nitric oxide in the gastrointestinal tract一氧化氮在胃肠道的作用.pdfVIP

Available online /supplements/10/S2/S4 Review Role of nitric oxide in the gastrointestinal tract Angel Lanas Servicio de Aparato Digestivo, Hospital Clinico Zaragoza, CIBERehd, IACS, Universidad de Zaragoza, C/ Domingo Miral s/n, 50009 Zaragoza, Spain Corresponding author: Angel Lanas, angel.lanas@ Published: 17 October 2008 Arthritis Research Therapy 2008, 10(Suppl 2):S4 (doi:10.1186/ar2465) This article is online at /supplements/10/S2/S4 © 2008 BioMed Central Ltd Abstract The search for new agents with which to manage pain and to reduce the attendant adverse events associated with NSAID Worldwide osteoarthritis (OA) affects more than 9.6% of men and 18% of women older that 60 years. Treatment for OA often use has led to the development of a new class of agents requires chronic use of selective or nonselective nonsteroidal anti- termed cyclo-oxygenase (COX)-inhibiting, nitric oxide (NO)- inflammatory drugs (NSAIDs), which have been associated with donating drugs (CINODs). CINODs are NO donors in which gastrointestinal and cardiovascular complications. An increased NO is coupled to an NSAID and could potentially improve the risk for upper gastrointestinal bleeding with NSAIDs alone and when gastrointestinal safety profile of traditional NSAIDs [6,7]. This combined with low-dose aspirin has been described in numerous studies. Although cyclo-oxygenase-2 inhibitors have been shown review discusses the known functions of NO in the gastro- to carry a lower risk for gas